As Ho and Bray reviewed literature and emphasised the protective effect of antioxidants in NFkB (redox sensitive transcription factor) induced
beta cell apoptosis.30 Moreover, CCT is known to decrease the levels of TNFa,16 a proinflammatory cytokine.
In this study, we demonstrated the induced diabetes mellitus diabetes during pregnancy significantly reduced in
beta cell density (Table I).
Lenzen, "Sensitivity profile of the human EndoC-[beta]H1
beta cell line to proinflammatory cytokines," Diabetologia, vol.
Beta cell function, insulin sensitivity and insulin resistance also improved among those who received zinc.
Currently, researchers are focusing on novel therapeutic strategies aimed at restoring, or at least preventing further loss of
beta cell mass in
beta cell deficit type 1 and type 2 diabetes patients as endogenous secretion of insulin is advantageous over exogenous insulin such as direct effect on hepatic (liver) glucose metabolism.
Monogenic syndromes of abnormal glucose homeostasis: Clinical review and relevance to the understanding of the pathology of insulin resistance and
beta cell failure.
"Combining Sanofi's and Evotec's
beta cell and stem cell expertise in drug discovery and development will enable optimal exploitation of the potential of stem cell derived human
beta cells for therapy and drug screening in diabetes," said Philip Larsen, vice president, global head of diabetes research and translational science, Sanofi.
The replication of
beta cells in normal physiology, in disease and for therapy.
Beta cell mass dynamics in Zucker diabetic fatty rats, Rosiglitazone prevents the raise in net cell death.
Type 1 diabetes is characterized by the progressive loss of pancreatic
beta cells caused by autoimmune attack [1].
In humans, pancreatic acinar cells can serve as progenitor for pancreatic islets; a concept with substantial implications for therapeutic efforts to increase insulin producing
beta cell mass in diabetic patients (Gao et al., 2003).