The gold spots of two selected vertical channels were self-assembled with
Angiogenin before carrying out the detection of anti-Angiogenin.
Hu, "Amyloidogenic variant of apolipoprotein A-I elicits cellular stress by atenuating the protective activity of
angiogenin," Cell Death and Disease, vol.
In supernatants collected from HUVECs cultured alone for 5 days, we measured detectable release of
angiogenin (2157 pg/mL), PDGF-AA (1292 pg/mL), PDGFBB (1500 pg/mL), endostatin (5523 pg/mL), thrombospondin (169 pg/mL), PIGF (149 pg/mL) and VEGF-D (143 pg/mL), CXCL8 (368 pg/mL), MMP-2 (116ng/mL), sVEGFR-1 (>200,000 pg/mL), and sVEGFR-2 (152 pg/mL), while HUVEC did not produce HGF or CXCL10, and detectable release of these latter two cytokines were not induced by addition of VPA or ATRA.
Angiogenesis has been attributed to many molecules including fibroblast growth factor, vascular endothelial growth factor, transforming growth factor [beta],
angiogenin, angiotropin, angiopoietin 1, tumor necrosis factor alpha, and thrombospondin [9-11].
Other proangiogenic factors, namely, IL-8 [30, 53-56], hepatocyte growth factor (HGF) [57, 58], erythropoietin [59],
angiogenin [60], macrophage migration inhibitory factor [61], neutrophil-activating factor [62], and TNF-[alpha] [63, 64], are all found at increased concentrations in the peritoneal fluid of patients with endometriosis.
In an effort to identify potential miRNAs involved in the regulation of angiogenesis and metastasis, Santhekadur and colleagues unraveled a linear pathway in which staphylococcal-nuclease-domain-containing-protein1 (SND1-) induced activation of NF-[kappa]B resulted in miR-221 expression and subsequent induction of angiogenic factors
angiogenin and chemokine (C-X-C motif) ligand 16 (CXCL16).
[7] Shapiro, R., and Valle, R., 1987, "Human placental ribonuclease inhibitor abolishes both angiogenic and ribonucleolytic activities of
angiogenin".
Strong positive associations were noted among total cholesterol and LDL cholesterol, as well as
angiogenin (ANG), TIMP metalloproteinase inhibitor 2 (TIMP2), [alpha]-2-HS-glycoprotein (AHSG), and apolipoprotein E.
In the next phase of their research, researchers will study whether mice that lack PHD2 expression develop more aggressive tumours, and whether blocking IL-8 or
angiogenin slows tumour growth, Giaccia said in a press release.
The study was carried out to determine the senstivity and specificity of oc-fetoprotein (AFP) and Desy-carboxyprothrombine (DCP) as a diagnostic marker for hepacellullar carcinoma (hcc) and to study the angiogenic and antiangiogenic factors like vascular endothlial growth factor (VEGF), basic fibroblast growth factor (bFGF),
angiogenin and endostatin in patients with hcc.