The researchers caution that, at this point, their findings pertain solely to
neural crest cells, but the same approach could be explored to understand cell differentiation in other tissues.
Neural crest cells are required for correct positioning of the developing outflow cushions and pattern the arterial valve leaflets.
Neural crest emigration: from start to stop [published online ahead of print January 25, 2018].
Craniofacial development is a complex multi-step process leading to the morphogenesis of the face and not only the
neural crest development is affected; Sox3 plays an equally crucial role in the pharyngeal region in craniofacial morphopathogenesis (Rizzoti & Lovell-Badge, 2007).
Sox5 has been shown to play important roles in regulating processes of embryonic development and cell fate determination, including
neural crest development (Martinez-Morales et al., 2010; Quintela et al., 2015).
In contrast, chondrocytes of the cartilaginous septum develop from
neural crest cells between the nasal cavities by the ninth week of embryonic development [46, 47].
A constant target of
neural crest cell anomalies,12 the chick thymus has remained a subject of interest for decades.13,14 Despite being intensively researched, volumetric numerical data on the chick thymus is lacking.
The teratogenecity of RA is manifested primarily by arresting the migration of cranial
neural crest cells (CNCC), to their destined tissues, including to the pharyngeal arches.
Neural crest cells play an important role in odontogenesis as reflected in the reciprocal induction that occurs between inner enamel epithelium and cells of the dental papilla (which originate from ectomesenchyme, a derivative of
neural crest cells).
They originate from the
neural crest cells which normally give rise to the adrenal medulla and sympathetic ganglia [4].
Neuroblastoma is an embryonal cancer of childhood arising from immature
neural crest cells of the sympathetic nervous system.