Herewith, we showed that intravenous application of MSCs in tumor-bearing mice significantly suppressed systemic antitumor immune response, reduced total number of lung-infiltrated DCs, macrophages, CD4+ T lymphocytes, CTLs, and
NK cells, and attenuated antitumor cytotoxicity of CTLs and
NK cells resulting with the expansion of metastatic lesions in the lungs.
International perspective on TCR & CAR T-cell and
NK cell therapy; and
Primary mediator of tissue damage is excessive cytokine production by
NK cells, macrophages and CTLs.2 Cytokines found at extremely high levels in the plasma of patients with HLH include interferon gamma (Ifn-g); tumor necrosis factor alpha (TNF-a); IL-6, IL-10, and IL-12; and the soluble IL-2 receptor (CD25).8-10
By building on our knowledge of the activating receptor NKp46, we have generated a technology to specifically induce tumor killing by
NK cells. This new technology platform is complementary to our innovative portfolio of first-in-class antibodies targeting immune checkpoints.
Since the immune system is a reticular and syntrophic entirety,
NK cell dysfunction also influences the function of the other parts of the system, especially effector T cells.
GTB-3550 (OXS-3550) is the Company's first Tri-specific
NK cell Engager (TriKE) product candidate being initially developed for the treatment AML.
After nutrient application, the function of
NK cells, TNF-a and receptor levels were measured by phytohemagglutinin (PHA) and ELISA.
To reach this conclusion, physicians devised a mathematical formula unlocking the complex interactive relationship between externally introduced viruses and
NK cells in addition to the immune system's existing
NK cells to calculate cancer cell-killing potency.
To investigate the changes in the immune system in term normal pregnancy, we first analyzed the subtypes of
NK cells in peripheral blood and decidua during normal pregnancy; then, we analyzed the expression of NCRs on the CD56+CD3-
NK cell; and, finally, we evaluated cytokine production in the peripheral blood and decidua in term pregnancy.
Studies have shown that the inhibition of immune function by stress response is caused by inhibition of natural killer cell (
NK cell) function.