It's one of the most exciting molecular targets in the cancer pathway," says Lily Yang of Emory University School of Medicine in Atlanta, who is also developing XIAP
As a long term customer of Xchanging and major user of the Genius and IRIS systems, we are pleased to play a part in shaping Xchanging's XIAP
We have been very encouraged by our preclinical results to date, which demonstrate that XIAP
may not only modify the progression of cell death, but may potentially reverse neuronal dysfunction as well.
Differentiation between benign and malignant mesothelial proliferations still relies on the histologic features of invasion, although a few markers, such as EMA, XIAP
, and GLUT-1, seem to favor a malignant process, whereas desmin favors a benign process.
A histone deacetylase inhibitor LBH589 down regulates XIAP
in mesothelioma cell lines which is likely responsible for increased apoptosis with TRAIL.
today announced that data from its phase 1/2 clinical trial of the XIAP
antisense oligonucleotide, AEG35156, will be highlighted in an oral presentation at the 50th Annual Meeting of the American Society of Hematology (ASH) in San Francisco, California, on December 9, 2008.
studies of HGSI's TRAIL receptor agonist monoclonal antibodies in combination with Ascenta's small molecule XIAP
inhibitors, will be presented in a poster session on Tuesday, April 17 (1pm-5pm).
18) At least 3 classes of IAPs composed of a total of 8 proteins have been identified in humans including the best known cIAP1, cIAP2, and XIAP
is pleased to announce the dosing of the first patient in a fifth phase 1 and 2 clinical oncology study of AEG35156, a second generation antisense therapeutic targeting XIAP
, a key member of the Inhibitor of Apoptosis protein family.
This new financing will permit Ascenta to accelerate and broaden the development of AT-101 in multiple cancer indications and advance our MDM2 and XIAP
preclinical programs," said Ascenta's CEO, Mel Sorensen, MD.
61) For antiapoptotic activity, increased expression of Bax, cIAP-1/2, XIAP
, Smac/Diablo, and survivin has been suggested to be associated with p38 MAPK activation in some cell line models.
OTCBB: NRGX) today announced findings from preclinical studies, which showed that the gene XIAP
(X-linked inhibitor of apoptosis) may prevent the progression of Huntington's disease.