1/2], elimination half life; CL/F, clearance after extravascular administration; Vz/F, volume of distribution
after extravascular administration.
3b) for the volume of distribution
, the blood alcohol concentration can be predicted as
The volume of distribution
during steady-state plasma drug concentration was calculated as (mean residence time) x (total body clearance).
Each entry begins with the known pertinent pharmacokinetic data, including half-life, volume of distribution
, fraction of protein-bound drug, p[K.
In the patients studied, IT-101 showed longer half life, lower clearance and lower volume of distribution
than seen in patients treated with other camptothecin-based drugs.
Conclusion and Clinical Relevance--Results indicated hydromorphone hydrochloride had high bioavailability and rapid elimination after IM administration, with a short terminal half-life, rapid plasma clearance, and large volume of distribution
in American kestrels.
25L/kg/h, steady state volume of distribution
(vdss) was 0.
Usefulness of the software algorithm was assessed based on its ability to eliminate sub-optimally positioned catheters that would likely limit drug distribution due to leakage into cerebrospinal fluid (CSF) spaces, and on the match of the volume of distribution
of the infusate as shown by SPECT and simulation.