Cycle

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Cycle

References in periodicals archive ?
Visual cycle modulators have received considerable attention in ophthalmology lately.
By selectively modulating the visual cycle in rod cells, we believe that ACU-4429 protects cone cells and by extension protects visual acuity.
EDT) Poster Title: Prolonged Rod Visual Cycle Suppression with ACU-4429 in Patients with Geographic Atrophy Program#/Poster#: 2044/D1062, Session 267 Location: Hall B/C
com) is a clinical-stage biotechnology company focused on leveraging promising science in visual cycle modulation (VCM) to develop new methods for treating blinding eye diseases that affect tens of millions of people worldwide.
In this single-center, randomized, double-masked, placebo-controlled, dose-escalation study, oral administration of ACU-4429 was well-tolerated and a dose-dependent modulation of the visual cycle was demonstrated using electroretinography (ERG), an established eye test.
Rosenfeld, a thought leader in ophthalmology, appreciates the scientific underpinning of visual cycle modulation, the clinical promise of ACU-4429, and the unmet medical need in dry AMD.
Data from the trial demonstrated a well-tolerated, dose-dependent modulation of the visual cycle using electroretinography (ERG), an established eye test in the evaluation of response and recovery of the retina that is used to help diagnose disease.