Immunohistochemistry staining of tyrosine hydroxylase
Positivity for tyrosine hydroxylase
should be assessed to render a diagnosis of paraganglioma when dealing with a keratin-negative neuroendocrine neoplasm (H) (hematoxylin-eosin, original magnifications X2.
Melatonin inhibits amphetamine-induced increase in alpha-synuclein and decrease in phosphorylated tyrosine hydroxylase
in SK-N-SH cells.
alpha]-methyl-DL-m-tyrosine ([alpha]-MMT), an inhibitor of the catecholamine-generative enzyme tyrosine hydroxylase
(Uretsky et al.
In addition, 3% of the hESC-derived neurons expressed tyrosine hydroxylase
, the rate-limiting enzyme for dopamine synthesis.
sup], Nurr1 can activate the transcription of tyrosine hydroxylase
and enhance the expression of DA transporter.
The combination of the two agents produced additive neuroprotective effects against dopamine depletion in the striatum and loss of tyrosine hydroxylase
neurons in the substantia nigra following chronic administration of a neurotoxic agent.
At the same time, CPF increased the expression of tyrosine hydroxylase
(TH), the enzymatic marker for the catecholamine phenotype, without affecting choline acetyltransferase (CHAT), the corresponding marker for the cholinergic phenotype.
The investigators compared the amounts of noradrenergic proteins and the relative immunoreactivity of tyrosine hydroxylase
in the postmortem brain tissue of seven long-term smokers and nine nonsmokers (Arch.
Recent data have shown a direct correlation of increased tyrosine hydroxylase
immunoreactivity in specific brain regions that display decreased calcineurin immunoreactivity.
Cardiac transmitter stores were depleted, leading to a reduced contribution of "leakage" to transmitter turnover and a reduced requirement for activation of tyrosine hydroxylase
, as assessed from measurements of cardiac spillover of DOPA.
An increase in dopaminergic neuronal death in the SN pars impacta was observed in treated rats, with no depletion in striatal dopamine but enhanced dopamine synthesis indicated by increased tyrosine hydroxylase
activity (McCormack et al.