Alkyldimethylaminoethyl ester iodides for Improved analysis of fatty acids by electrospray ionization tandem mass spectrometry
State Newborn Screening in the Tandem Mass Spectrometry
Era: More False-Positive Results.
Judy Stone, who works for TPMG Kaiser Regional Laboratory, has been using tandem mass spectrometry
technologies for years to conduct testing of fewer than 100 samples per day.
The growth of mass spectrometry and more specifically liquid chromatography coupled to tandem mass spectrometry
(LC-MS/MS)  continues to accelerate in the clinical laboratory.
Cooks advanced this analytical capability with the introduction of tandem mass spectrometry
in which selected ions generated from complex mixtures are further fragmented and the masses of the fragment ions determined.
Topics include nucleolar localization of adenovirus core proteins, tandem mass spectrometry
, the transforming activities of adenovirus oncogenes, large-scale purification and crystallization of adenovirus hexon, and phylogenetic analysis of adenovirus sequences.
The researchers used tandem mass spectrometry
to retrospectively analyze dust samples taken from a 350- to 420-head pig-fattening farm from 1981 to 2000.
The use of a wide range of state-of-the-art techniques including tandem mass spectrometry
, time-of-flight mass spectrometry, and NMR were all critical to the identification of the metabolite and confirmation of its identity.
Successful and cost-efficient replacement of immunoassays by tandem mass spectrometry
for the quantification of immunosuppressants in the clinical laboratory.
Analytical methods that employ UltraPerformance Liquid Chromatography (UPLC(R)) coupled with tandem mass spectrometry
can screen for more than 100 different drug residues at a time at concentrations of less than 10 ng/mL, a big improvement in speed, efficiency, and sensitivity over the traditional seven-plate bioassay method.
Dass starts with the basics of operation and then covers modes of ionization, mass analysis and ion detection, tandem mass spectrometry
, hyphenated separation techniques, organic mass spectrometry, inorganic mass spectrometry, structure determination of proteins and peptides and their post-translational modifications, higher order structures, oligosaccharides, characterizations of lipids, and structure determination of oligonucleotides.
Tandem mass spectrometry
provided confirmation of PbTx-3, which also increased for the time points between 0.