73 (c) (*) Means with different superscript are significantly different at 5% level of significance using DMRT Table 3: Percent growth inhibition of crude extracts of Trichoderma species Crude extract concentration ([micro]l/ml) Growth inhibition (%) TA100
typhimurium strains TA98 and TA100
in the presence (+S9) and absence (-S9) of metabolic activation.
The negative control was DMSO, and the positive controls were 2-nitrofluorene (3 pg/plate) for TA98 - S9 and YG1041 -S9; sodium azide (3 pg/plate) for strain TA100
- S9; 2-amino-anthracene (0.
typhimurium strain TA100
specifically requires a base-pair substitution to become autotrophic for histidine (McCann et al.
Mutagenic activity: Mutagenic activity investigation of seed and seedling crude extracts was performed against two test strains of Salmonella TA98 and TA100
for evaluation of their potential ability to cause cancer.
Moreover, other alkaloids from this plant, such as dictamine, gamma-fagarine, ptelein, and kokusagine, had a strong mutagenic effect on Salmonella typhimurium strain TA98 without S9 mix, and moderate mutagenic effects with and without S9 mix on TA100
strain (PAULINI et al.
Apart from the above groups another set of spontaneous revertant and positive control group (TA98 with DEXON TA100
with sodium azide) was set.
Steviol proved to be non-mutagenic in reverse mutation assays (Ames test) using Salmonella typhimurium TA100
, TA98, TA102 and TA97 .
In Salmonella typhimurium strains TA100
and TA102, MX induces damage of the DNA by base-pair substitution (Hemming et al.
The mutagenic activity was determined by applying the Salmonella/microsome test, known as the Ames test, using TA98 and TA100
strains of S.
Blackberry extracts inhibit UV-induced mutagenesis in Salmonella typhimurium TA100
2007) has found that a polyphenolic mixture derived from sesame-seed perisperm (SSP) exhibited desmutagenic activity against hydrogen peroxide, and benzo[a]pyrene in TA98 and/or TA100
and biomutagenic activity against sodium azide in strain TA100
of Salmonella typhimurium.