Marker

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Related to Surrogate marker: bioequivalence trial

Marker

A slang term for documentation indicating that a debt is owed.
References in periodicals archive ?
In HIV clinical research, the study endpoints are usually a change in surrogate markers.
In the early 1990s, activist pressure lead to reforms at the FDA that allowed for the accelerated approval of therapies for life-threatening conditions if 1) there were few effective options to treat that condition and 2) if there were surrogate markers (see p.
Raloxifene protected against breast cancer in women having surrogate markers indicative of low lifetime estrogen exposure but reduced risk by an even greater margin in those with high lifetime estrogen exposure.
Why, then, can't we solve this problem by developing an immune-based surrogate marker, like viral load for antiretrovirals?
It must be a surrogate marker for something that we don't understand," Dr.
The effect of BL-1020 on dopamine levels was assessed by monitoring serum prolactin, a surrogate marker for dopamine antagonism.
Madyoon, "because atherosclerosis occurs in blood vessels throughout the body, plaque buildup in carotid arteries is a good surrogate marker for build up in the coronary arteries indicating a higher risk of heart attack and stroke.
Quantity is not a valid surrogate marker for quality.
1] Although it relied on relatively limited surrogate marker data, and although it acknowledged the technical deficiencies of resistance tests, the panel nevertheless recommended the use of these assays in a variety of clinical scenarios.
The indication for use of ProAmatine in the treatment of symptomatic orthostatic hypotension is based primarily on a change in a surrogate marker of effectiveness, an increase in systolic blood pressure measured one minute after standing, a surrogate marker considered likely to correspond to a clinical benefit.
Height loss as a surrogate marker for vertebral osteoporosis was evaluated in a study of patients attending a lymphoma clinic.
This finding left some in attendance to question whether stress hyperglycemia caused poor outcomes or was just another surrogate marker like SOFA scores.