44) It is of note that D-dimer formation and DIC appears to play a larger role in EVD than in Marburg virus
Clinical reports of past Marburg virus
outbreaks suggest that people can be exposed longer to the virus than monkeys before showing symptoms.
The anti-MARV nucleoprotein-targeting siRNAs have been designed to protect against all known strains of Marburg virus
, but will not protect against the Ebola virus.
victims suffer sudden onsets of fever, vomiting, joint pains, headache and internal bleeding.
Investigators conducted two pilot studies in cynomolgus monkeys to assess the efficacy of AVI-6003 against lethal challenge with Marburg virus
Scientists had previously demonstrated that the vaccine could avert Marburg virus
when administered a month before exposure (SN: 7/16/05, p.
disease (MVD) is caused by Marburg virus
(MARV; family Filoviridae, which also includes Ebola viruses).
Priority will be given to viral haemorrhagic diseases such as Ebola, Marburg virus
disease and Crimean-Congo haemorrhagic fever.
Furthermore, the caves are home to Rousettus aegyptiacus bats, which are reservoirs for Marburg virus
in other parts of Africa (5).
To make the vaccines, the researchers stripped the vesicular stomatitis virus of a particular gene and replaced it either with a gene that encodes a protein on the Marburg virus
or with a gene for a protein on the Ebola virus.
Some examples include: Lassa fever, Marburg virus
, Ebola virus, Bolivian haemorrhagic fever, Korean hemorrhagic fever, Crimean-Congo hemorrhagic fever and Dengue hemorrhagic fever.
The other genus in the family Filoviridae is Marburgvirus, consisting of Marburg virus
and Ravn virus (termed marburgviruses; MBGV), both of which are associated with severe disease (Marburg virus
disease [MVD]) in humans (3,4).