Precision and accuracy of the international normalized ratio
in oral anticoagulant control.
Warfarin pharmacodynamics and importance to treatment (a) Pharmacodynamic effect Dependent on Timing Anticoagulant effect Factor VII levels 24-72 hr Antithrombotic effect Factor II levels (thrombin) 96-120 hr Pharmacodynamic effect Clinical importance Anticoagulant effect Clinically insignificant elevation of INR, still able to form thrombin clot Antithrombotic effect Clinically significant elevation of INR, less likely to form clot (a) INR, international normalized ratio
In-house calibration of the International Sensitivity Index or calibration curve for the determination of the International Normalized Ratio
After rVIIa administration, there were significant decreases in prothrombin time, international normalized ratio
, and partial thromboplastin time.
People who are prescribed blood thinners are required to follow strict nutritional guidelines in order to maintain healthy International Normalized Ratio
Influence of storage time and temperature on international normalized ratio
(INR) levels and plasma activities of vitamin K dependent clotting factors.
Sensitivity to warfarin, advanced age, and an extreme elevated international normalized ratio
(INR) are independent risk factors for prolonged delay to return of the INR to within the therapeutic range.
Higher-risk aortic patients will be maintained using warfarin (Coumadin(R)) at reduced International Normalized Ratio
(INR) levels of between 1.
can be taken with Warfarin without affecting international normalized ratio
Data on testing for the international normalized ratio
, available for 748 patients on warfarin, showed that on average these patients spent 55% of the time they were followed in the INR target range of 2.
Efforts to standardize the Quick PT have provided a common means for expressing patient PT results, the International Normalized Ratio
(INR), and have provided a method for quantitative comparison of thromboplastin reagents (4).
Once enrolled, patients had their international normalized ratio
(INR) determined via two methods: usual venipuncture and a point-of-care device using fingerstick whole blood sampling.