Progress in and deterrents to orthotopic liver transplantation, with special reference to survival, resistance to hyperacute rejection
, and biliary duct reconstruction.
Investigators placing pig organs in other animal species have stemmed endothelial cell activation and the resulting hyperacute rejection
by depleting a prospective recipient's store of alpha-gal antibodies before the xenotransplant.
The major strategies used to reduce hyperacute hyperacute rejection
such as depletion of anti-Gal antibodies and genetic engineering of swine to express human complement regulatory proteins to decrease complement deposition, might impact host defenses against viral infection (Meije et al.
Even postulating a greatly diminished or eliminated risk of hyperacute rejection
, immunologic barriers to xenotransplantation will probably be more significant than those of allotransplantation.
4 /PRNewswire/ -- La Jolla Pharmaceutical Company (Nasdaq: LJPC) today announced that it has completed the laboratory testing and development of a new, five-fold-more potent Toleragen(R) candidate designed to arrest the production of antibodies responsible for hyperacute rejection
in xenotransplantation, the use of animal organs for human transplantation.
This induces complement activation and results in hyperacute rejection
of the xenograft (Good et al.
assistant professor of surgery, whose gene sequencing work contributed a key understanding that allowed PPL to move forward and achieve two more significant milestones involving the creation of cloned pigs lacking the gene associated with hyperacute rejection
, thus removing a major immune barrier between pig and human and making transplants from animals to humans more feasible.
The report, published February 8Th by the Department of Health, notes that genetic modification of source animals to knock-out the genes responsible for hyperacute rejection
and to add new genes necessary to control later rejection is promising but remains in the very early stages.
vice president of research and development at Nextran, who today is presenting at IBC's Xenotransplantation Conference in San Diego, stated "Through this collaboration with Cytel, we expect to minimize the most significant immunological barrier to transplantation of pig organs -- hyperacute rejection
This pig sugar (alpha 1,3 galactose) triggers an immune response in the human patient, leading to hyperacute rejection
of the transplanted organ or cell within minutes.