Time-lapse movies indicate that these mutants fail to form stable growth cones
, which is a required first step for successful axon regeneration.
Calcium regulation of neurite elongation and growth cone
Dissociated adult Rana pipiens motoneuron growth cones
turn up concentration gradients of denervated peripheral nerve-released factors.
The differential expression of receptors or receptor complexes on the growth cone
and their ligand-dependent interactions, along with some intracellular adaptors and mediators, link the external guidance cues with the internal environment of the axon and result in the specificity and polarity of particular axons.
Bryan's introduction of reserve growth cones
served to reinforce the attack on the language and intent of the directive.
A key difference between growth cones
and retraction bulbs involves the degree of microtubule assembly.
The Role of miRNAs in Axonal Retraction and Growth Cone
The arrival of acetylcholine seems to lead to a rapid influx of calcium into the cell, the appearance of many cellular fingers on the side of the growth cone
facing the needle, and, finally, turning.
Figure 1A shows a Pol-Scope image of a growth cone
in which several different birefringent components can be distinguished.
It's a very clear proof that these proteins are playing an instructive role in giving a direction to the growth cones
," Culotti says.
This trend continued into the first half of 1990, as growth in depository credit all but ceased--though overall debt growth continued at a moderate pace--and M3 fell well below the lower bound of its annual growth cone
All of these behaviors depend on precise regulation of growth cone