While dose dependent, extrapyramidal symptoms
typically occur at a rate that is comparable to that seen with placebo at doses less than or equal to 6 mg/day.
were more common among patients in the paliperidone group than among those in the placebo group.
At the same time, Zyprexa IntraMuscular (olanzapine for injection) was associated with a low risk of developing movement disorders known as extrapyramidal symptoms
In addition, the study showed no statistically significant differences in the occurrence of extrapyramidal symptoms
(EPS) between patients treated with Zyprexa IntraMuscular and those treated with placebo.
And the Food and Drug Administration has moved to reassure drug companies that if they have a drug that does not worsen psychosis, depression, or extrapyramidal symptoms
but does improve negative symptoms or functionality, they will consider an indication for that drug, Dr.
Iloperidone's binding to a number of dopamine and serotonin receptors provides a favorable safety profile on adverse symptoms, such as weight gain, extrapyramidal symptoms
, akathisia and prolactin elevation.
In addition, the study confirmed that Zomaril possesses an excellent tolerability profile with no extrapyramidal symptoms
, little weight gain and no effect on serum prolactin.
Treatment with LY2140023 was not observed to have certain adverse events that often occur with currently approved schizophrenia medications, including increased prolactin elevations, extrapyramidal symptoms
(involuntary movements or muscle stiffness), or weight gain.
Clinicians were encouraged to reduce the dose of each antipsychotic to mitigate extrapyramidal symptoms
Zomaril(TM), which has an antagonistic activity on a wide spectrum of brain receptors for dopamine and serotonin, with preferential affinity for 5HT2A serotonin receptors in humans, had previously shown activity against both positive and negative symptoms of schizophrenia, as well as a low liability for inducing extrapyramidal symptoms
(movement disorders) in Phase II clinical trials.
Generally, it can be stated that extrapyramidal symptoms
are not much of a problem for patients taking second-generation antipsychotic drugs except for the problem of akathisia with ziprasidone treatment, which should be taken into account" when considering which drug to prescribe, said Dr.
MUNICH, Germany, January 4 /PRNewswire/ -- A new study published today in the European Archives of Psychiatry and Clinical Neuroscience demonstrates that quetiapine (SEROQUEL) and risperidone (RISPERDAL) have equivalent efficacy in the treatment of patients with schizophrenia exhibiting predominately negative symptoms, however quetiapine showed superior tolerability especially with respect to extrapyramidal symptoms