cell

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cell

an independent team of operatives who work together in a CELLULAR MANUFACTURING production environment.
References in periodicals archive ?
T cells are critical immune effector cells, and alteration in their function can have grave consequences on responses to primary infection and the acquisition of immunity.
sup][8],[19] Consistent with previous studies, the findings of the current study demonstrated that, similar to the number and effector cell response of CD8[sup]+ Tem, the level of serum sTREM-1 expression was also significantly increased after IL-12 treatment and significantly decreased after adding rapamycin.
In the present study, we addressed the immunotoxic potential of the herbicide PRN on the effector cells of cell-mediated immunity, CTLs.
Like other proteins in the inhibitor of apoptosis protein family, survivin binds specifically to terminal effector cell death proteases, specifically caspase-3 and -7.
The ADCC Reporter Bioassay uses an alternative readout at an earlier point in ADCC MOA pathway: the activation of gene transcription through the NFAT (nuclear factor of activated T-cells) pathway in the effector cell.
CAR technology activates T cell and Natural Killer cell functionality within one effector cell population, sourced from healthy donor or cord blood.
Results: Recent evidence has shown that miRNAs are involved in regulating fibrosis by targeting different substrates in the molecular processes that drive fibrosis, such as immune cell sensitization, effector cell activation, and extracellular matrix remodeling.
ADCC is a mechanism of cell-mediated immune defense in which an effector cell of the immune system, including Natural Killer (NK) cells, actively lyses a target cell.
Literature shared positive prediction of sting reactivity through allergy specific activity (the allergen-specific IgE to total IgE ratio; sIgE/T-IgE analysis) involving extensive effector cell activation along with allergen-specific IgE antibody's concentration, affinity (tightness of binding), clonality (epitope specificity) observations.
Studies at two independent laboratories showed that rhIL-7 markedly improved host survival, blocked apoptosis of CD4 and CD8 T cells, restored IFN- production, and improved immune effector cell recruitment to the infected site.
This can be achieved either by engineering the antibody itself to optimize Fc effector functions such as ADCC and CDC, or adding payload functions to the antibody by incorporating a second targeting specificity to recruit immune effector cells or fusing it with toxins or cytokines.
Xencor has applied its XmAb antibody engineering technology to improve the potency of XmAb2513 by engineering its Fc region to improve binding affinity to Fc(gamma) receptors, thereby enhancing engagement of immune effector cells and tumor-cell killing.