Toxin

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Toxin

Any poisonous substance a living thing produces as part of its metabolic or other natural process. That is, toxins themselves are not living things, but are produced by living things. Toxins are defined by the Biological Weapons Convention.
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Adenosine diphosphate ribosylation of aminoacyl transferase II and inhibition of protein synthesis by diphtheria toxin.
Experimenting with a birth-control vaccine that uses the tetanus rather than diphtheria toxin to stimulate antibodies is G.
Yet the protein does not harm other laboratory-grown cells that are very sensitive to diphtheria toxin but lack MSH receptors.
Although diphtheria toxin is not normally toxic to mouse cells, in their experiments the researchers will add a molecule to abnormal mouse DGCs that binds with the toxin.
Cambridge, UK) to remove the T cell epitopes from Diphtheria toxin while retaining its cytotoxic potency.
Strain Diphtheria toxin 16S rRNA CD443 Nontoxigenic FJ409572 CD448 Nontoxigenic FJ409573 CD449 Nontoxigenic FJ409574 CD450 Nontoxigenic FJ409575 C.
ONTAK is a genetically engineered fusion toxin protein consisting of the amino acid sequences for the enzymatically-active portion of diphtheria toxin fused to the sequence of human interleukin-2, resulting in a molecule that is cytotoxic for cells bearing the target IL-2 receptor.
He was one of the first to demonstrate the production of immunity by killed cultures of disease organisms and to show that a mixture of diphtheria toxin and antitoxin confers immunity.
Anjin Group, with operations in Maryland and Massachusetts, is a biotechnology company developing a broad-based therapeutic platform for blood cancers, brain cancer and other diseases based on the fusion of a modified form of diphtheria toxin to proteins capable of selectively targeting cancerous and diseased cells.
Insegia is comprised of a synthetic peptide derived from gastrin (G17), bound to an inactive form of the diphtheria toxin (DT), which together elicit a powerful immune response against gastrin.
The leading drug BC-819, used in these clinical trials is a double stranded DNA plasmid construct that incorporates the gene for diphtheria toxin (DTA) under the regulation of the promoter sequence for H19 gene.
Three of the five patients in the trial developed an improved immune response to HIV and also to diphtheria toxin.

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