Further studies on cytochrome P450
metabolism will continue to provide clinicians with guidelines for appropriate agents to use when circumstances arise warranting the use of multiple-drug regimens.
However, the Human Genome Project has identified a cohort of extra-hepatic cytochrome P450s
that are over-expressed during the malignant progression of most cancers (both solid and hematological malignancies) but not in normal tissue.
Expression of modified human cytochrome P450
2E1 in Escherichia coli, purification, and spectral and catalytic properties.
Pymetrozine is hydroxylated by CYP6CM1, a cytochrome P450
conferring neonicotinoid resistance in Bemisia tabaci.
Characterization of the human cytochrome P450
forms involved in metabolism of tamoxifen to its a-hydroxy and a,4-dihydroxy derivatives.
Researchers have used genetically engineered hepatoma-based cell lines that express either alcohol dehydrogenase, cytochrome P450
2E1, or both of these enzymes (VA-13, E47, and VL-17A cells, respectively) to study the effects of ethanol metabolism on proteasome function (Dai et al.
2) GB 2 408 509 Astex Therapeutics Limited Crystal structure of cytochrome P450
3A4 and its use.
We obtained spectral interactions between Roundup or glyphosate and the active site of the purified cytochrome P450
aromatase by measuring the absorbance of the preparations from 375 to 475 nm.
Degradation and Its Clinical Relevance (Mingxiang Liao, Ping Kang, Bernard P.
Keywords: Mistletoe extract; Herb-drug interaction; Hepatocyte viability; Cytochrome P450
inhibition; Cytochrome P450
John's wort boosts hepatic cytochrome P450
3A4 metabolic activity.
2C is an EDHF synthase in coronary arteries.