Critics of glucosamine and chondroitin
have pointed to the few studies that did not reveal a significant benefit compared to placebo.
To my knowledge, the Fred Hutch study is the first to directly demonstrate a statistically significant reduction in high-sensitivity CRP following daily consumption of glucosamine and chondroitin
sulfate, in a controlled trial," noted Dr.
For patients receiving chondroitin
, "the final difference was 55% prevention in joint space narrowing, which was statistically significant at the end of the second year," he said.
By positive control, we mean that they compared glucosamine and chondroitin
to something that was known to work, in this case, a Cox-2 inhibitor.
Editor's Note: Chondroitin
sulfate is a component of joint cartilage and is available as a prescription drug in Europe.
Straus, director of the National Center for Complementary and Alternative Medicine, said that if the ancillary study shows that glucosamine and chondroitin
can preserve cartilage, further research in this area would be even more compelling.
Glucosamine and chondroitin
, two of the many components of cartilage, are found in some foods and can also be made in our bodies.
Studies continue to show benefits--especially for knee pain and stiffness--of the combination of dietary glucosamine and chondroitin
(both nutrients used in the formation of new cartilage).
A study published in the New England Journal of Medicine (NEJM) this week finds that the combined use of two dietary supplements - glucosamine and chondroitin
- provide significant pain relief from the most common form of arthritis.
The double-blind, placebo-controlled study examined the effects of FruiteX-B with a combination of glucosamine and chondroitin
versus glucosamine and chondroitin
alone on joint health and flexibility.
Compared with placebo, glucosamine, chondroitin
and their combination did not reduce joint pain or have an impact on narrowing of joint space, the authors concluded.
Clegg's study findings should be discounted ("Glucosamine and Chondroitin
Fall Short for Knee OA," Dec.