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gonorrhoeae, could regulate chemokine receptors and pathways with known roles in HIV infection in cervical epithelial cells to enhance susceptibility of the genital tract to infection.
The stromal derived factor-1/ CXCL12-CXC chemokine receptor 4 biological axis in non-small cell lung cancer metastases.
Chemokine receptor CCR5 promotes leukocyte trafficking to the brain and survival in West Nile virus infection.
Since inflammation plays a major role in the pathogenesis of cancers and CCR5 plays an important role in inflammation, the aim of this study was to investigate the association of human papillomavirus (HPV) infection and cancer progression to chemokine receptor 5 (CCR5) polymorphism.
CCR5 and CXCR4 chemokine receptor expression and beta-chemokine production during early T cell repopulation induced by highly active antiretroviral therapy.
While HIV has subverted the chemokine receptors CCR5 and CXCR4 for its own use as an entry co-receptor, their normal functions are to transduce signals in response to extracellular ligands.
The first co-receptor that HIV latches onto to enter the cell is called CC chemokine receptor 5 [CCR5].
CXCR7 is a chemokine receptor that was 'deorphanized' (a function was discovered for the protein encoded by a gene of previously unknown function) at ChemoCentryx through the company's proprietary EnabaLink Drug Discovery engine.
When investigators created mice lacking the chemokine receptor CXCR4, which is one that HIV exploits, the rodents died as embryos, their hearts and blood vessels riddled with defects.
29, 2013 /PRNewswire/ -- TaiGen Biotechnology Company, Limited ("TaiGen") announced the results from the US Phase IIa trial of TG-0054, a CXC chemokine receptor 4 (CXCR4) antagonist, in stem cell transplantation will be presented in an Oral Session at the 55th ASH Annual Meeting and Exposition (December 7-10, 2013) in New Orleans, LA, U.
In the study, the researchers demonstrate that the chemokine CCL5 helps to direct the recruitment of EPCs to sites of wounding by acting on the chemokine receptor CCR5.