An endophytic fungus from Camptotheca acuminata that produces camptothecin
XMT-1001 is a conjugate of the broad-spectrum cytotoxic camptothecin
(CPT) that employs Mersana's Fleximer(R) platform.
The pathway leading to apoptosis for sodium butyrate and camptothecin
does not require p53 expression.
Attenuation of camptothecin
production and negative relation between hyphal biomass and camptothecin
content in endophytic fungal strains isolated from Nothapodytes nimmoniana Grahm (lcacinaceae).
These preliminary results build on our preclinical studies, which showed that XMT-1001 has greater efficacy in human tumor xenograft models than comparable doses of irinotecan, an agent with a similar mechanism of action as camptothecin
and that is approved to treat patients with colon cancer.
The CZ48 drug, together with Camptothecin
and its other derivatives, has a potential market of US$1 billion in USA alone.
Evodiamine, a dual catalytic inhibitor of type 1 and 11 topoisomerases, exhibits enhanced inhibition against camptothecin
The Pacific West Cancer Fund also supports radon testing in schools, camptothecin
plant medicinal research, nutritional studies for cancer prevention, and the distribution of cancer prevention literature to schools and libraries.
CRLX101 is a tumor-targeted nanopharmaceutical containing camptothecin
, an inhibitor of both topoisomerase 1 and hypoxia-inducible factor-1 alpha (HIF-1).
Similar time- and concentration-dependent behavior of camptothecin
concentration between patients and animals.
The improved toxicity towards camptothecin
resistant cells further supports its inhibitory mechanism which is different from camptothecin
, and its therapeutic potential.
Aphios[R] Corporation today announced that it has entered into a subcontract with SAIC-Frederick, a subsidiary of Science Applications International Corporation, to develop phospholipid nanoencapsulated camptothecin
, Camposomes[TM], for the treatment of pancreatic and other cancers, supporting the NCI Alliance for Nanotechnology.