For immunoprecipitation studies, mouse monoclonal antibody against human CREBBP (C-1, 20 [micro]g; Santa Cruz Biotechnology) was incubated with 10 [micro]l of protein A Sepharose beads (Amersham Pharmacia) at 4[degrees]C for 4 h (Imakawa et al.
Similar levels of transcription factor CREBBP, JUN, ETS2 mRNAs were found this time period whereas IFNT mRNA declined (Figure 1A).
Published research suggests that genetic alterations of CREBBP and EP300 appear in up to 25% of bladder cancer cases," said Charles M.
Mutations in these HAT genes, EP300 and CREBBP, are common in bladder cancer," said Jonathan E.
We are excited to begin testing mocetinostat, an oral HDAC inhibitor, in patients with DLBCL and FL that harbor CREBBP
and EP300 genetic alterations," said Anas Younes, M.
Initiated a multi-center registration-enabling study in patients with bladder cancer who have mutations of CREBBP
or EP300 genes
3 percent of the 71 relapsed-ALL patients carried alterations in the DNA sequence of CREBBP