These data raised the intriguing possibility that CD95
could actually promote the growth of tumours," said lead author Marcus Peter of Northwestern University.
Activation of the CD95
system increases with disease progression in human immunodeficiency virus type 1-infected children and adolescents.
Since the CD95
ligand is expressed in many types of cancer, there is tremendous potential for the use of APG101.
These findings indicate that a genetic predisposition to an increased expression of CD95
may help to protect from severe malaria, possibly by rendering a type of white blood cell more susceptible to programmed cell death.
It is also observed that the highly active antiretroviral therapy in HIV infected individuals can decrease the CD95
expression on naive T cells (18).
In the phase II trial, glioblastoma patients expressing a certain biomarker associated with the CD95
ligand experienced the greatest benefit from treatment with APG101.
FLICE is activated by association with the CD95
death-inducing signaling complex (DISC).
323) Although CD95
(FAS) is uniformly expressed in LyP and C-ALCL, (324) inhibition of this pathway may also be secondary to upregulation of c-FLIP.
Phosphatidylinositol 3'-kinase blocks CD95
aggregation and caspase-8 cleavage at the death-inducing signaling complex by modulating lateral diffusion of CD95
Similarly, other proteins involved in apoptosis, such as bc1-2, bax, CD95
, or specific caspases, cannot currently be used for determining sensitivity or resistance to anticancer treatments [for a review, see Ref.
The data demonstrates that treatment with APG101, a CD95
ligand-binding fusion protein, in combination with radiotherapy is an innovative concept that has shown clinical superiority in all study endpoints compared to treatment with radiotherapy alone.
Trans-cinnamaldehyde is partially effective through up-regulation of CD95
(Zhang et al.