The study, which is to be published in the Journal of Biolagical Psychiatry, tested a chromium picolinate-based supplement as a proprietary nutrition therapy for atypical depression
Patients requiring referral to a psychiatrist include those with suicidal ideation or severe depression, aggressive ideation, bipolar disorder, atypical depression
, psychotic depression, substance abuse, or treatment resistance.
Carbohydrate cravings, weight gain and unexplained fatigue are hallmark symptoms of atypical depression
, a common, but frequently undiagnosed, depressive disorder estimated to affect as many as one-third of depressed patients.
Concerns about side effects--primarily hypertensive crisis--and dietary restrictions have lead many clinicians to curtail their use of MAOls, but increased knowledge of these drugs can help psychiatrists reconsider this treatment option, particularly for patients with atypical depression
Chromium picolinate appears to be effective for improving the symptoms of atypical depression
, said Dr.
In addition, MAOIs have been shown to have superior efficacy compared with the TCAs in patients with atypical depression
,[63-66] a condition that is characterized by prominent anxiety symptoms.
Forty clinical trials demonstrate the safety and efficacy of Chromax for insulin resistance associated with diabetes, obesity, cardiovascular disease and atypical depression
Akiskol and Benazzi (35) suggest that atypical depression
may be a subtype of the bipolar spectrum.
Those patients could benefit from using monoamine oxidase (MAO) inhibitors, since those drugs are most effective in atypical depression
or hysteroid dysphoria, which often occurs with irritability, sensitivity to rejection, loneliness, anger, and eating and sleeping too much.
A large and growing body of scientific data suggests that chromium picolinate may help lower some risk factors for diseases associated with insulin resistance, such as obesity, cardiovascular disease, type 2 diabetes, Polycystic Ovarian Syndrome (PCOS) and even atypical depression