Developing animal models
that are more predictive of efficacy is an iterative process.
2004) are associated with a pattern of behavioral effects commensurate with deficient 5HT function, resembling that seen in animal models
of depression (Cairncross 1984; Cryan et al.
Gishizky continued, "In the case of the NOD mouse, many therapies that have looked promising in this animal model
have not demonstrated efficacy in treating patients with type 1 diabetes.
In part because of biologists' growing capability to genetically engineer mice, the number of these animal models
has exploded over the past decade.
This new animal model
adds another dimension to our drug discovery capabilities," said Dr Steven Petrou, Vice President CNS Research at Bionomics.
Weiss, your lab is currently using an animal model
that is proving highly useful.
Now we have demonstrated that this same therapy prevents the recurrence of secondary cancers in animal models
Innovative approaches to isolate, characterize, and identify totipotent and multipotent stem cells from nonhuman biomedical research animal models
, as well as to generate reagents and techniques to characterize and separate those stem cells from other cell types, is encouraged.
The work bolsters hopes that this animal model
can help scientists assess the potential of various drugs against the AIDS-causing virus, or HIV.
The document contains the results of additional animal model
studies requested since the filing of a Pre-Pre-IND document and subsequent conference call with the FDA.
However, attempts to establish an animal model
that faithfully replicates human smallpox have historically been unsuccessful.
has introduced the world's first drug testing service utilizing a genetically engineered animal model
expressing a key human protein for atherosclerosis and coronary heart disease.