Synuclein, amyloid precursor protein
(APP), super oxide dismutase and prions are copper/zinc superoxide scavengers that can all form aggregates associated with neurodegeneration.
The amyloid precursor protein
is typically the focus of research related to Alzheimer's disease.
Our experiments looked at the consequences of decreased ubiquilin-1, and showed that it's necessary for the proper handling of amyloid precursor protein
(APP)," he said.
Mary's Hospital Medical School in London found that some people with an inherited, early-onset form of Alzheimer's shared a specific mutation in their gene for amyloid precursor protein
(APP) (SN: 2/23/91, p.
PRX-03140 is highly selective for the 5-HT4 receptor in the brain, and preclinical studies have shown that it improves cognitive function, as well as increases levels of acetylcholine, soluble amyloid precursor protein
(sAPP) and brain-derived neurotrophic factor (BDNF) in regions of the brain known to be important for memory.
The team from Massachusetts General Hospital researchers reports that there is a very close link between elevated levels of iron in the brain and the enhanced production of the amyloid precursor protein
, which in Alzheimer's disease breaks down into a peptide that makes up the destructive plaques.
a leading medical diagnostics/research company specializing in the development of monoclonal antibodies and diagnostic assays for cancer, infectious disease, and neurodegenerative disease, today announced the availability of a polyclonal antibody specific for sAPPbeta, a cleavage product of amyloid precursor protein
In a related development had underscores the importance of amyloids, investigators report in the July 18 NATURE that mice genetically engineered to over-produce an amyloid precursor protein
(of which beta amyloid is a fragment) develop plaques similar to those seen in Alzheimer's.
Plaque deposits are formed when amyloid precursor protein
(APP), found widely throughout the body, releases itself into fragments, called beta-amyloids, which in turn form plaque.
The defect, located on chromosome 21, causes cells to insert a single incorrect amino acid while manufacturing a substance called amyloid precursor protein
Sugaya attributed this effect to Posiphen's ability to decrease the synthesis of amyloid precursor protein
Now scientists have identified an enzyme, alpha secretase, which cleaves the amyloid precursor protein
(APP) without forming beta-amyloid.