Our study confirmed that age, plasma LD concentration on admission, and absolute neutrophil count
were independent predictors of adverse outcome.
We look forward to determining whether the intriguing increases in absolute neutrophil count
and bioavailability seen in the Phase I studies will continue to be evident in patients receiving chemotherapy in Phase II," said George J.
The most common grade 3 or greater toxicities observed in the treatment arms (ERBITUX plus FOLFIRI, ERBITUX plus FOLFOX, FOLFIRI alone, or FOLFOX alone) were diarrhea (22%, 14%, 15%, and 10%, respectively) and absolute neutrophil count
(34%, 38%, 27%, and 36%, respectively).
Prescribing health care practitioners, dispensing pharmacists and FazaClo patients must be registered in the FazaClo Patient Registry, which will compare patient information against the National Non-Rechallenge Masterfile and maintain a continuing record of total white blood cell (WBC) counts and absolute neutrophil count
(ANC) values and related information for all patients who receive the FazaClo brand of clozapine.
Febrile neutropenia, the primary endpoint of the study, was defined as an absolute neutrophil count
(ANC) less than 1 x 10(9)/L and temperature greater than or equal to 38 degrees C.
2 degrees C and an absolute neutrophil count
(ANC) less than 0.
In patients with multiple myeloma, hematologic toxicity (based on platelet count, absolute neutrophil count
, hemoglobin level, or neutropenia with fever) may require dose reduction, delay in administration, or suspension of DOXIL and/or VELCADE
Absolute neutrophil count
, the primary pharmacodynamic marker for G-CSF products, exhibited the same response profile to dosing with INS-19 as with Neupogen(R).